Loss-of-Function Mutations inABCA1and Enhanced β-Cell Secretory Capacity in Young Adults
نویسندگان
چکیده
منابع مشابه
Loss-of-Function Mutations in ABCA1 and Enhanced β-Cell Secretory Capacity in Young Adults
Loss-of-function mutations affecting the cholesterol transporter ATP-binding cassette transporter subfamily A member 1 (ABCA1) impair cellular cholesterol efflux and are associated with reduced HDL-cholesterol (HDL-C) levels. ABCA1 may also be important in regulating β-cell cholesterol homeostasis and insulin secretion. We sought to determine whether loss-of-function ABCA1 mutations affect β-ce...
متن کاملLoss-of-Function Mutations in ABCA1 and Enhanced b-Cell Secretory Capacity in Young Adults
Loss-of-function mutations affecting the cholesterol transporter ATP-binding cassette transporter subfamily A member 1 (ABCA1) impair cellular cholesterol efflux and are associated with reduced HDL-cholesterol (HDL-C) levels. ABCA1 may also be important in regulating b-cell cholesterol homeostasis and insulin secretion. We sought to determine whether loss-offunction ABCA1 mutations affect b-cel...
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15 صفحه اولCarriers of Loss-of-Function Mutations in ABCA1 Display Pancreatic β-Cell Dysfunction
OBJECTIVE Abnormal cellular cholesterol handling in islets may contribute to beta-cell dysfunction in type 2 diabetes. beta-Cell deficiency for the ATP binding cassette transporter A1 (ABCA1), which mediates the efflux of cellular cholesterol, leads to altered intracellular cholesterol homeostasis and impaired insulin secretion in mice. We aimed to assess the impact of ABCA1 dysfunction on gluc...
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ژورنال
عنوان ژورنال: Diabetes
سال: 2014
ISSN: 0012-1797,1939-327X
DOI: 10.2337/db14-0436